Freckled Anglers can be kept in a variety of aquarium environments ranging from nano cubes to reef aquarium setups. They should be provided with plenty of live rock, coral or fake coral decorations in order to provide them with areas to perch and blend into their environment. They prefer a sand substrate and require plenty of live rock for hunting and shelter (they also appreciate coral rubble that they can blend into and setup an ambush). Anglers can have quite a biological impact for their size and their home should be provided with efficient biological and mechanical filtration along with the use of a protein skimmer. They are a reef safe species that will not harm corals, but they may sometimes eat small shrimp and will definitely dine on small fish; for this reason, most hobbyists tend to keep them in a FOWLR environment. They normally coexist well with other species, but should not be housed with puffers or triggers as they will soon be missing their fishing gear (esca and illicium). Any tank mates that will fit into their large mouths can potentially become dinner and should be avoided.
Freckled Anglers are predatory, ambush hunting, carnivores that mainly eat small fish and shrimp in the wild. In the aquarium they should be fed live (possibly gut-loaded), small fish, brine shrimp, and ghost shrimp. They can also be conditioned to accept frozen and other prepared or vitamin-enriched meaty foods from a feeding stick (wiggled around near them) such as krill, silver sides, chopped crustacean flesh, chopped fresh fish, chopped mussels, chopped scallops, and chopped clams.